Life Unfolding How the Human Body Creates Itself (Audible Audio Edition) Jamie A Davies Napoleon Ryan Audible Studios Books
Download As PDF : Life Unfolding How the Human Body Creates Itself (Audible Audio Edition) Jamie A Davies Napoleon Ryan Audible Studios Books
Where did I come from? Why do I have two arms but just one head? How is my left leg the same size as my right one? Why are the fingerprints of identical twins not identical? How did my brain learn to learn? Why must I die? Questions like these remain biology's deepest and most ancient challenges. They force us to confront a fundamental biological problem How can something as large and complex as a human body organize itself from the simplicity of a fertilized egg?
A convergence of ideas from embryology, genetics, physics, networks, and control theory has begun to provide real answers. Based on the central principle of "adaptive self-organization", it explains how the interactions of many cells, and of the tiny molecular machines that run them, can organize tissue structures vastly larger than themselves, correcting errors as they go along and creating new layers of complexity where there were none before. Life Unfolding tells the story of human development from egg to adult, from this perspective showing how our whole understanding of how we come to be has been transformed in recent years.
Highlighting how embryological knowledge is being used to understand why bodies age and fail, Jamie A. Davies explores the profound and fascinating impacts of our newfound knowledge.
Life Unfolding How the Human Body Creates Itself (Audible Audio Edition) Jamie A Davies Napoleon Ryan Audible Studios Books
"The history of a man for the first nine months preceding his birth would probably be far more interesting than all the three score and ten years that follow it" - Samuel Taylor Coolidge. The book starts with this quote which is an excellent preamble to the contents. How a fertilized egg can transform itself through cell division into a human body with all its cell diversity is, for the vast majority of us, mind blowing. Life unfolding starts with the embryo an discusses aspects of what we know about how life develops. It can be hard to follow at times as the names of proteins and tissue regions are not easily memorized but the contents are fascinating. Life unfolding takes us through aspects of biological development looking at areas involved in conception all the way up until death. The topics are chosen to give us a sense of what people are focused on as well as how biological science is done.The book is split into 3 core parts. The first is titled First Sketch. The author starts at the beginning and looks at the journey of a fertilized egg. It discusses the potential mechanical mechanisms that a cell employs to divide effectively. The author communicated the initial conditions well so that the complexity of processes like cell division become more understandable to us. By this I mean people don't usually think about why cell division in and of itself should be difficult ones the nucleus has divided but by describing the blindness of molecules to the geometry of the cell, the process of self organization is quickly realized to be highly non-trivial. The author discusses how the embryo moves to attach itself to the mother, how it uses mechanical principles to orient itself and start to create structure from symmetry. The author describes how the feedback mechanisms used by proteins leads to complex and differentiating behavior from uniform cell samples. The author discusses how a spherical set of cells can start to create the conditions of a body formation. One starts to get the sense of how uniformity can turn into heterogeneous behavior all through locally generated feedback mechanisms.
In the second section, Adding Details, the author moves on to discuss how the true complexity of our bodies starts to evolve. We get a sense of how stem cells start to branch depending on the feedback signals in the local area of the cells that leads to organ formation. We learn how protein concentrations affect gene activation which feedback to protein concentration and how all of these can combine to create bias in cellular movement that helps organize new tissues and organs. The author discusses the kidneys at length and how arms and legs are created can form using feedback effects. The author also discusses the differences between the chromosomes of the sexes, namely the XY and XX pairs, and how physiology is a function of certain gene representations and feedback effects due to how XY and XX behave differently and how inhibited Y chromosomes can evolve to look like women in all things but reproductive ability.
In the final core section, Refinement, the author discusses later stage life. In this section we move past the quote the book starts with and start to focus on internal evolution, the author discusses the nervous system and articulates both the incredible complexity of our neural networks as well as how feedback effects between neurons guides the way connections are formed. The author discusses the Vitruvian man and how the proportions of the body can be thrown off due to certain cellular process malfunctions. The author ends by noting how our body is constantly replenishing our cells and then dives into how the regeneration process is propagated.
Life unfolding gives the reader a sense of how symmetry is broken in cellular life. It describes aspects of the incredible complexity of our cellular life by focusing on stylized examples that are relatively simple dynamical systems that can lead to unintuitive complex outcomes. It is extremely interesting but at times overwhelming. There are a multitude of genes and proteins that the reader will be unfamiliar with and the cross referencing means the reader will have to flip back to earlier sections quite often to remind themselves of details. The fact that the author can communicate aspects of how cell complexity arises to the novice is a remarkable feat and I encourage people to read this book.
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Life Unfolding How the Human Body Creates Itself (Audible Audio Edition) Jamie A Davies Napoleon Ryan Audible Studios Books Reviews
When we think of intelligence we think of what we see and what we do and why we do; this exploration deep within the intelligence of the cells of the human body makes pales anything we think our "rational minds" produce. I had no idea the depth, creativity and importance of how cells operate. This discussion is about our body but it is representative of the process in all of life and it is amazing.
I think this is an absolutely fantastic book. It describes the building of a person starting right after fertilization. His explanations all along the way are very clear, concise, and understandable. What impressed me most, besides the excellent writing, is just how we could have evolved into such a complex structure, built up from one cell. To me the process is awe inspiring.
This is pretty much the basic information you would find in a developmental biology textbook, but in more understandable terms, and only in the context of humans. If that interests you, then I would suggest picking up this book!
Wow. I loved this book. A real "a ha!" moment doesn't come by every day-- one where you say, "wow. I totally get it. That's so NEAT!!", but I had a number of them reading this book, and it was kind of euphoric. I'm so glad Mr Davies undertook to explain this complex yet un-blueprinted undertaking at this level. The book is detailed enough to be mind-blowing and enlightning, but accessible enough to not require a professor, paid university credits, and a thick textbook. This wasn't an easy balance to write, I'm sure, but Davies did an excellent job on a very worthwhile read. My daughter gets it next.
Reading science books is a lifelong pastime for me, and Life Unfolding is definitely my favorite EVER. Each page reveals an amazing event in the development of a fetus, to the extent that I can't wait to read the next page and have my mind blown again. Some of the passages get a little complex and the author generally has simple diagrams to help, though I feel a few more would be appropriate. Still my favorite science book ever. A must read.
The reader should have at least a high school biology class to be able to comprehend the principles in this book. However, an intelligent reader these days can make progress in understanding if he/she is diligent and resourceful. The book is well worth the time someone can devote to understanding his/her world and the good science that is explained in this book. We are a lot closer to understanding life and how it creates itself than most people realize, if only they would prepare to comprehend basic science from the bottom up. I am still reading it and finding new understanding as I go along. For me, the disclosures of how the body increases and develops is a mystery solved and one I was always longing to know!
This book does three things well.
1. It helps people understand basic biochemistry and cell signaling within the context of human development.
2. It explains biology deeper than 9th grade levels metaphors do. (Chapter 1 alone destroys the blueprint/DNA metaphor very artfully)
3. It answers how humans are put together giving details every step of the way.
The book also gives many examples of physiological processes and explains how cells interact with each other and their environment. It's easy to read and the diagrams are easy to understand.
"The history of a man for the first nine months preceding his birth would probably be far more interesting than all the three score and ten years that follow it" - Samuel Taylor Coolidge. The book starts with this quote which is an excellent preamble to the contents. How a fertilized egg can transform itself through cell division into a human body with all its cell diversity is, for the vast majority of us, mind blowing. Life unfolding starts with the embryo an discusses aspects of what we know about how life develops. It can be hard to follow at times as the names of proteins and tissue regions are not easily memorized but the contents are fascinating. Life unfolding takes us through aspects of biological development looking at areas involved in conception all the way up until death. The topics are chosen to give us a sense of what people are focused on as well as how biological science is done.
The book is split into 3 core parts. The first is titled First Sketch. The author starts at the beginning and looks at the journey of a fertilized egg. It discusses the potential mechanical mechanisms that a cell employs to divide effectively. The author communicated the initial conditions well so that the complexity of processes like cell division become more understandable to us. By this I mean people don't usually think about why cell division in and of itself should be difficult ones the nucleus has divided but by describing the blindness of molecules to the geometry of the cell, the process of self organization is quickly realized to be highly non-trivial. The author discusses how the embryo moves to attach itself to the mother, how it uses mechanical principles to orient itself and start to create structure from symmetry. The author describes how the feedback mechanisms used by proteins leads to complex and differentiating behavior from uniform cell samples. The author discusses how a spherical set of cells can start to create the conditions of a body formation. One starts to get the sense of how uniformity can turn into heterogeneous behavior all through locally generated feedback mechanisms.
In the second section, Adding Details, the author moves on to discuss how the true complexity of our bodies starts to evolve. We get a sense of how stem cells start to branch depending on the feedback signals in the local area of the cells that leads to organ formation. We learn how protein concentrations affect gene activation which feedback to protein concentration and how all of these can combine to create bias in cellular movement that helps organize new tissues and organs. The author discusses the kidneys at length and how arms and legs are created can form using feedback effects. The author also discusses the differences between the chromosomes of the sexes, namely the XY and XX pairs, and how physiology is a function of certain gene representations and feedback effects due to how XY and XX behave differently and how inhibited Y chromosomes can evolve to look like women in all things but reproductive ability.
In the final core section, Refinement, the author discusses later stage life. In this section we move past the quote the book starts with and start to focus on internal evolution, the author discusses the nervous system and articulates both the incredible complexity of our neural networks as well as how feedback effects between neurons guides the way connections are formed. The author discusses the Vitruvian man and how the proportions of the body can be thrown off due to certain cellular process malfunctions. The author ends by noting how our body is constantly replenishing our cells and then dives into how the regeneration process is propagated.
Life unfolding gives the reader a sense of how symmetry is broken in cellular life. It describes aspects of the incredible complexity of our cellular life by focusing on stylized examples that are relatively simple dynamical systems that can lead to unintuitive complex outcomes. It is extremely interesting but at times overwhelming. There are a multitude of genes and proteins that the reader will be unfamiliar with and the cross referencing means the reader will have to flip back to earlier sections quite often to remind themselves of details. The fact that the author can communicate aspects of how cell complexity arises to the novice is a remarkable feat and I encourage people to read this book.
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